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KMID : 0380020160310010040
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Korean Journal of Biotechnology and Bioengineering
2016 Volume.31 No. 1 p.40 ~ p.45
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Characterization and Inhibitory Activity of Lactobacillus plantarum MG989 and Lactobacillus fermentum MG901 Isolated from Vaginal Microbiota of Korean Women against Gardnerella vaginalis and Candida albicans
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Paek Nam-Soo
Lee Youn-Yeop
Han Seul-Hwa
Kang Chang-Ho
So Jae-Seong
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Abstract
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Vaginitis, also known as vaginal infection and vulvovaginitis, is an inflammation of the vagina and possibly vulva. The three main kinds of vaginitis are bacterial vaginosis, vaginal candidiasis, and trichomoniasis. The purpose of this study was to characterize Lactobacillus plantarum MG989 and L. fermentum MG901 isolated from the vaginas of healthy Korean women in terms of their inhibitory activity against the vaginitis associated pathogens such as Gardnerella vaginalis and Candida albicans. Co-culture experiments showed that the two Lactobacillus strains MG989 and MG901 significantly reduced the viability of G. vaginalis and C. albicans. Also, the two strains were resistant to bile acid up to 1% and their autoaggregation rates were as high as 83.33%. Further studies are underway to demonstrate that the two strains can be applied as pharmaceutical agents for recovering healthy vaginal ecosystem.
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KEYWORD
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Vaginitis, Gardnerella vaginalis, Candida albicans, Lactobacillus plantarum MG989, Lactobacillus fermentum MG901
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